Anti-GAPDH Antibody (clone 6C5) IHC-plus

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td class=srcSitecss_ProductDetailLabelTD style=width: 120px; font-weight: bold; vertical-align: top;labelarget:/label/td
td class=srcSitecss_ProductDetailBoxRightTD style=padding-left: 10px; vertical-align: top;Rabbit GAPDH/td
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td class=srcSitecss_ProductDetailLabelTD style=width: 120px; font-weight: bold; vertical-align: top;labelHost:/label/td
td class=srcSitecss_ProductDetailBoxRightTD style=padding-left: 10px; vertical-align: top;Mouse/td
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td class=srcSitecss_ProductDetailLabelTD style=width: 120px; font-weight: bold; vertical-align: top;labelReactivity:/label/td
td class=srcSitecss_ProductDetailBoxRightTD style=padding-left: 10px; vertical-align: top;Rabbit, Human, Monkey, Mouse, Rat, Bat, Cat, Dog, Pig, Sheep, Chicken, Xenopus, Fish, African green monkey, Green monkey, Tube-nosed batnbsp;span class=srcSitecss_AntibodyDetailBoxCommentSPAN style=color: rgb(128, 128, 128); font-size: 10px;(tested or 100% immunogen sequence identity)/span/td
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td class=srcSitecss_ProductDetailLabelTD style=width: 120px; font-weight: bold; vertical-align: top;labelClonality:/label/td
td class=srcSitecss_ProductDetailBoxRightTD style=padding-left: 10px; vertical-align: top;IgG1 Monoclonal [6C5]/td
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td class=srcSitecss_ProductDetailLabelTD style=width: 120px; font-weight: bold; vertical-align: top;labelConjugations:/label/td
td class=srcSitecss_ProductDetailBoxRightTD style=padding-left: 10px; vertical-align: top;Unconjugated. Also available conjugated withnbsp;a href=https://www.lsbio.com/antibodies/anti-gapdh-antibody-clone-6c5-biotin-elisa-if-immunofluorescence-ihc-ip-wb-western-ls-c188574/196477Biotin/a,nbsp;a href=https://www.lsbio.com/antibodies/anti-gapdh-antibody-clone-6c5-dy680-elisa-if-immunofluorescence-ihc-ip-wb-western-ls-c188575/196478DY680/a,nbsp;a href=https://www.lsbio.com/antibodies/anti-gapdh-antibody-clone-6c5-dy800-elisa-if-immunofluorescence-ihc-ip-wb-western-ls-c188576/196479DY800/a,nbsp;a href=https://www.lsbio.com/antibodies/anti-gapdh-antibody-clone-6c5-hrp-elisa-if-immunofluorescence-ihc-ip-wb-western-ls-c188577/196480HRP/a./td
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td class=srcSitecss_ProductDetailLabelTD style=width: 120px; font-weight: bold; vertical-align: top;labelPurification:/label/td
td class=srcSitecss_ProductDetailBoxRightTD style=padding-left: 10px; vertical-align: top;Protein A purified/td
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td class=srcSitecss_ProductDetailLabelTD style=width: 120px; font-weight: bold; vertical-align: top;labelModifications:/label/td
td class=srcSitecss_ProductDetailBoxRightTD style=padding-left: 10px; vertical-align: top;Unmodified/td
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h3 class=srcSitecss_AntibodyDetailBoxHeadingPaddingH3 style=padding: 6px 0px 1px 8px; margin: 2px 0px; color: rgb(26, 86, 158); font-size: 16px; font-family: Calibri, Verdana, Arial, Helvetica, sans-serif;Applications/h3
div class=srcSitecss_AntibodyDetailBoxDIV style=border: 1px solid rgb(192, 192, 192); border-radius: 6px; padding: 6px 4px 6px 6px; margin-right: 4px;label class=srcSitecss_AntibodyAssayListLABEL style=font-weight: bold; vertical-align: top; width: 100px; display: inline-block; padding-left: 5px;Approved:/labelnbsp;
ul class=srcSitecss_AntibodyAssayListUL style=display: inline-block; margin: 0px; padding-bottom: 3px; width: 400px;
liIHC/li
liIHC - Paraffin (10 micro;g/ml)/li
liIHC - Frozen/li
liImmunofluorescence/li
liWestern blot/li
liImmunoprecipitation/li
liELISA/li
li(applications tested for the base form of this product only)/li
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td class=srcSitecss_ProductDetailLabelTD style=width: 120px; font-weight: bold; vertical-align: top;labelImmunogen:/label/td
td class=srcSitecss_ProductDetailBoxRightTD style=padding-left: 10px; vertical-align: top;GAPDH antibody was raised against rabbit muscle GAPDH./td
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td class=srcSitecss_ProductDetailLabelTD style=width: 120px; font-weight: bold; vertical-align: top;labelSpecificity:/label/td
td class=srcSitecss_ProductDetailBoxRightTD style=padding-left: 10px; vertical-align: top;Recognizes glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a 36kD multifunctional protein whose main function is to catalyze the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate, in conjunction with inorganic phosphate and nicotinamide adenine dinucleotide (NAD). This reaction is an important energy yielding step in carbohydrate metabolism. GAPDH has also been shown to translocate to the nucleus under a variety of stressors, most of which are associated with oxidative stress, whereby it mediates cell death. A further report has shown that GAPDH binds to several proteins that are responsible for neurodegenerative diseases, such as amyloid precursor protein and Huntingtin./td
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td class=srcSitecss_ProductDetailLabelTD style=width: 120px; font-weight: bold; vertical-align: top;labelPresentation:/label/td
td class=srcSitecss_ProductDetailBoxRightTD style=padding-left: 10px; vertical-align: top;PBS, 0.09% sodium azide/td
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td class=srcSitecss_ProductDetailLabelTD style=width: 120px; font-weight: bold; vertical-align: top;labelStorage:/label/td
td class=srcSitecss_ProductDetailBoxRightTD style=padding-left: 10px; vertical-align: top;4deg;C or -20deg;C, Avoid freeze-thaw cycles./td
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td class=srcSitecss_ProductDetailLabelTD style=width: 120px; font-weight: bold; vertical-align: top;labelRestrictions:/label/td
td class=srcSitecss_ProductDetailBoxRightTD style=padding-left: 10px; vertical-align: top;For research use only./td
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h3 class=srcSitecss_AntibodyDetailBoxHeadingPaddingH3 style=padding: 6px 0px 1px 8px; margin: 2px 0px; color: rgb(26, 86, 158); font-size: 16px; font-family: Calibri, Verdana, Arial, Helvetica, sans-serif;About GAPDH/h3
div class=srcSitecss_AntibodyDetailBoxDIV style=border: 1px solid rgb(192, 192, 192); border-radius: 6px; padding: 6px 4px 6px 6px; margin-right: 4px;label style=font-weight: bold;Uniprot:nbsp;/labela href=http://www.expasy.org/uniprot/p04406 target=_blankP04406/anbsp;label style=font-weight: bold;NCBI:/labelnbsp;a href=http://www.ncbi.nlm.nih.gov/nuccore/nm_002046 target=_blankNM_002046/anbsp;a href=http://www.ncbi.nlm.nih.gov/protein/np_002037.2 target=_blankNP_002037.2/a
plabel style=font-weight: bold;Synonyms:/labelnbsp;GAPDH Antibody, A1 40 kd subunit Antibody, Activator 1 40 kd subunit Antibody, G3PD Antibody, GAPD Antibody, G3pdh Antibody, Rfc40 Antibody, Rf-c 40 kd subunit Antibody/p
label style=font-weight: bold;Description:/labelnbsp;Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton.
div class=srcSite_ProductInfoColumnMoreLink style=padding: 10px 0px 4px; margin-right: 4px;a href=https://www.lsbio.com/targets/gapdh/g253(More About GAPDH)/a/div
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