Anti-CXCR1 (extracellular)
- 貨號 Cat. No.
- ACR-011
- 規格 Size
- 50 µl 0.2 ml
Description
Anti-CXCR1 (extracellular)
CXC Chemokine Receptor 1
CXC Chemokine Receptor 1
| Product#: | ACR-011 |
| Sizes: |
| 50 µl |
| 0.2 ml |
| Host: |
Rabbit. Type: Polyclonal. |
| Epitope: |
Peptide (C)SNITDPQMW DFDDLN, corresponding to amino acid residues 2-16 of human CXCR1 (Accession P25024). |
 |
| Putative epitope location: |
Extracellular, N-terminus. |
| Homology: |
| Specific to human CXCR1. |
| Reactivity Confirmed: |
| Human. |
Applications:
| Western Blotting: |
 | Western blot analysis of CXCR1 in Jurkat cell lysates: 1. Anti-CXCR1 (extracellular) antibody (#ACR-011), (1:200). 2. Anti- CXCR1 (extracellular) antibody, preincubated with the control peptide antigen. |
| Flow Cytometry: |
 |
Indirect Flow Cytometry of Jurkat living cells: _____ Unstained cells _____Anti-CXCR1 (extracellular) antibody (#ACR-011), (10ç—¢/5x105 cells). |
Chemokine receptors belong to the seven transmembrane domain G-Protein Coupled Receptors and are differentially expressed in diverse cell types. In leukocytes, chemokines coordinate development, differentiation, anatomic distribution, trafficking, and effector functions and thereby regulate innate and adaptive immune responses.
To date, 18 chemokine receptors are known and designated as CXCR1-5, CCR1-11, XCR1, and CX3CR1 based on their specific chemokine preferences.
The CXC chemokine receptors specifically bind and respond to cytokines of the CXC chemokine family. CXCR1 and CXCR2 were the first chemokine receptor subtypes to be defined. They are the only known mammalian receptors for ELR+ CXC chemokines [CXC chemokines which contain the tripeptide motif glutamic acid-leucine-arginine (ELR)N-terminal to the first cysteine].
CXCR1 and CXCR2 both bind IL-8, with similar high affinity; they do not bind other types of chemokines. CXCR1 and CXCR2 are the major chemokine receptors expressed on neutrophils. They appear to operate mainly in acute inflammation and innate immunity.
Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of the human CXCR1. Anti-CXCR1 (extracellular) antibody (#ACR-011) can be used for western blot and indirect flow cytometry applications. It was specifically designed to recognize human CXCR1.