Anti-Cavpan α1
- 貨號 Cat. No.
- ACC-004
- 規格 Size
- 50 μl 0.2ml
Description
Anti-Cavpan a1
| Product#: | ACC-004 |
| Sizes: |
| 50 ml |
| 0.2 ml |
| Host: |
| Rabbit. |
| Epitope: |
Peptide (C)DNFD YLTRD WSILG PHHLD, corresponding to residues 1506-1524 of rat Cav1.2 (a 1C) (Accession P22002) |
 |
| Putative epitope location: |
Intracellular, C-terminal part. |
| Homology: |
Cav1 family (a 1C, a 1D, a 1F, a 1S) from all known species - identical; Cav2 family (a 1A, a 1B, a 1E) from all known species - 17/19 residues identical. |
| Reactivity Confirmed: |
Rat, mouse. |
Applications:
| Western Blotting: |
 | Western blotting of rat brain membranes: 1. Anti-pan Cav a1 antibody (#ACC-004) (1:200). 2. Anti-pan Cav a1, preincubated with the control peptide antigen. |
| References: |
| 1. Bonilla, M. and Cunningham, K.M. (2002) Sci. STKE 127, PE17. |
| 2. Wu, X. et al. (2004) J. Biol. Chem. 279, 43392. |
| 3. Iwasaki, S. et al. (2000) J. Neurosci. 20, 59. |
| 4. Mark, M.D. and Herlitze, S. (2000) Eur. J. Biochem. 267, 5830. |
Ca2+ ions regulate many cellular processes such as secretion, proliferation, and apoptosis
and they are also cofactors of many proteins.1,2 In neurons, Ca2+ entry through voltage-dependent Ca2+ (Cav) channels triggers neurotransmitter release. Fast synaptic transmission in the mammalian central nervous system (CNS) is mediated by several high voltage-dependent Ca2+ channels.3 Five types of Ca2+ channels are expressed in the CNS: the L-type (Cav1), N-type (Cav2.2), P/Q-type (Cav2.1), R-type (Cav2.3), and the T-type (Cav3).4 Each Cav channel is a multimeric protein composed of a pore forming a1 subunit and the auxiliary b(Cavb), a2d and g subunits. There are four known Cavb subunits, in addition to four a2d subunits and eight g subunits.4
The Anti-Cavpan a1 antibody is directed against an intracellular epitope at the C-terminus of the a1 subunit recognizes the high voltage gated calcium channels, Cav1 and Cav2 subfamily members.