Anti-CaV3.1

Anti-Ca_v3.1 (a1G)

Product#:

ACC-021

Sizes:

50 ml

0.2 ml

Voltage-dependent Ca²⁺ channels provide a pathway for rapid influx of Ca²⁺ into cells,  

which plays a crucial role in both electrical and metabolic signaling.¹ 

T-type currents are transduced via channel proteins encoded by three genes that  

compose a subfamily within the Cav channel family.^2-3 

The activity of T-type channels contributes to several known physiological and pathophysiological  

phenomena including burst firing in neurons, pace making activity in the heart and secretion  

from endocrine tissues.² There are three cloned T-type channel isoforms.  

Ca_V3.1 (a1G) and Ca_V3.2 (a1H) are widely distributed whereas the expression of Ca_V3.3 (a1I) 

is restricted to the central nervous system.²  

Ca_V3.1 and Ca_V3.2 are also expressed in the kidney, but little is known about their physiological role there.  

The epitope was chosen according to Andreasen et al.⁴

Host:

Rabbit.

Epitope:

Peptide MDEEEDGAGAEESGQPRSFTQL(C),  corresponding to amino acid residues 1-22 of rat CaV3.1.

Putative epitope location:

Cytoplasmic, N-terminus.

Homology:

Human - 20/22 amino acid residues identical.

Reactivity Confirmed:

Rat.

Applications:

Western Blotting:

Western blotting.

Western blot analysis of  Cav3.1 in rat brain membranes: 1. Anti-Cav3.1 antibody (#ACC-021), (1:200).   2. Anti-Cav3.1 antibody, preincubated with the control peptide antigen.

References:

1. Serrano, J.R. et al. (1999) J. Gen. Physiol. 114, 185.

2. Perez-Reyes, E. (2003) Physiol. Rev. 83, 117.

3. Wain, H.M. et al. (2002) Nucleic Acids Researc 30, 169.

4. Andreasen, D. et al. (2000) Am.J.Physiol. 279, F997.