Anti-Cav1.3
- 貨號 Cat. No.
- ACC-005
- 規格 Size
- 50 μl 0.2ml
Description
Anti-Cav1.3 (a1D)
| Product#: | ACC-005 |
| Sizes: |
| 50 ml |
| 0.2 ml |
| Host: |
| Rabbit. |
| Epitope: |
Peptide (C)DNKV TIDDY QEEAE DKD (CND1), corresponding to residues 859-875 of rat Cav1.3 (a 1D) (Accession P27732). |
 |
| Putative epitope location: |
Intracellular loop between II and III domains. |
| Homology: |
Hamster and mouse (16/17), human(15/17), chicken (12/17) residues identical. |
| Reactivity Confirmed: |
Rat, mouse. |
Applications:
| Western Blotting: |
 | Western blotting of rat brain membranes: 1. Anti-Cav1.3 antibody (#ACC-005) (1:200). 2. Anti-Cav1.3 antibody, preincubated with the control peptide antigen. |
| Immunohistochemistry: |
Expression of Cav1.3 in rat dorsal root ganglion. |
 |
Immunohistochemical staining of Cav1.3 in adult rat dorsal root ganglion (DRG) Anti-Cav1.3 antibody (#ACC-005). Staining appeared in clusters of cells (green) but not in axons. Staining of neurofilament 200 demonstrates partial overlap with Cav1.3 in neuronal staining but not in axons (red). |
| References: |
| 1. Catterall, W.A. et al. (2003) Pharmacol. Rev. 55, 579. |
| 2. http://www.iuphar-db.org/iuphar-ic/calcium.html. |
| 3. Mangoni, M.E. et al (2003) Proc. Natl. Acad. Sci.100, 5543. |
| 4. Zhang, Z. et al. (2005) Circulation. 112, 1936. |
All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptors. While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous.1,2
The CaV1.3 channels are also expressed, as are other L-type channels, in neurons and neuroendocrine cells. However, accumulated data has shown the expression of CaV1.3 in heart and suggests that it plays a major role in the generation of cardiac pacemaker activity.3,4
Several peptidyl toxins have been described that are specific L-type channel blockers. These include the Mamba toxins Calcicludine (#C-650), Calciseptine (#C-500) and FS-2 (#F-700). So far no selective blocker for one of the CaV1 isoforms has been described.