Anti-B2 Bradykinin Receptor
- 貨號 Cat. No.
- ABR-012
- 規格 Size
- 50 μl 0.2ml
Description
Anti-B2 Bradykinin Receptor
| Product#: | ABR-012 |
| Sizes: |
| 50 µl |
| 0.2 ml |
| Host: | ||
Rabbit.
|
| Epitope: |
 |
| Putative epitope location: |
| C-terminus, Intracellular. |
| Homology: |
| Reactivity Confirmed: |
Rat, mouse. |
Applications:
| Western Blotting: |
 | Western blot analysis of B2 Bradykinin Receptor in rat brain lysate: 1. Anti-B2 Bradykinin Receptor antibody (#ABR-012), (1:1000). 2.Anti-B2 Bradykinin Receptor antibody preincubated with the control peptide antigen. |
| Immunohistochemistry: |
Expression of B2 Bradykinin Receptor in mouse spinal cord |
 |
Immunohistochemical staining B2 Bradykinin Receptor (BKBR2) in mouse spinal cord using Anti- B2 Bradykinin Receptor antibody (#ABR-012). A, B2 Bradykinin Receptor (red) appears in several spinal cord neurons (white triangles). B, Parvalbumin (green) appears in neurons. C, merge of B2 Bradykinin Receptor and parvalbumin shows co-expression in several neurons (white triangles) but not all (left pointing arow in C). The blue counterstain is DAPI. |
Kinins are small peptides produced rapidly following tissue injury that serve as important modulators of inflammation and pain. In the periphery, the actions of kinins include vasodilatation, increased vascular permeability, stimulation of immune cells, and induction of pain. Kinins in the central nervous system (CNS) seem to initiate a similar cascade of events leading to neural tissue damage, as well as long lasting disturbances affecting blood-brain barrier function.1
Kinins, such as Bradykinin (BK), Lys-BK, desArg9-BK, and Lys-desArg9-BK, exert their action via two distinct receptors: the B1 Bradykinin receptor (BKRB1) and the B2 Bradykinin receptor (BKRB2). BKRB2 is activated by BK and Lys-BK while desArg9-BK and Lys-desArg9-BK activate BKRB1.2 Activation of BKRB2 liberates mediators of vascular tone, fibrinolysis, and pain. BKRB2, which mediates most of the physiological effects of kinins, as well as BKRB1, represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases.
Both BKRB1 and BKRB2 are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily and share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxy terminus.
BKRB2 is constitutively and widely expressed throughout the CNS and peripheral nervous system and on various cell types including endothelial cells, nerve fibers, leukocytes, and mast cells.3-5
Alomone Labs is pleased to offer a highly specific antibody directed against an intracellular epitope of human Bradykinin 2 receptor (BKRB2). The Anti-BKRB2 antibody (#ABR-012) can be used in Western blot analysis and Immunohistochemistry applications. It has been designed to recognize BKRB2 from human, rat, and mouse samples.