Anti-b2-Adrenoceptor (extracellular)
- 貨號 Cat. No.
- AAR-016
- 規格 Size
- 50 μl 0.2ml
Description
Anti-b2-Adrenoceptor (extracellular)
| Product#: | AAR-016 |
| Sizes: |
| 50 µl |
| 0.2 ml |
| Host: |
| Rabbit. |
| Epitope: |
Peptide (C)NGSRAPDHDVTQERDE corresponding to amino acid residues 15-30 of mouse b2-Adrenoceptor (Accession P18762). |
 |
| Putative epitope location: |
Extracellular, N-Terminus. |
| Homology: |
| Human-15/16 amino acid residues identical; rat-14/16 amino acid residues identical. |
| Reactivity Confirmed: |
Rat. |
Applications:
| Western Blotting: |
 | Western blot analysis of rat heart (lanes 1 and 3) and lung (lanes 2 and 4) lysates: 1, 3. Anti-b2-Adrenoceptor (extracellular) antibody (#AAR-016), (1:200). 2, 4. Anti-b2-Adrenoceptor (extracellular) antibody, preincubated with the control peptide antigen. |
| Immunohistochemistry: |
Expression of ADRB2 in rat lung |
 |
Immunohistochemical staining of paraffin-embedded section of rat lung using Anti-ADRB2 (extracellular) antibody (#AAR-016), (1:100). ADRB2 is expressed in the respiratory epithelium. Hematoxylin is used as the counterstain. |
Adrenoceptors (also called adrenergic receptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions.
The Adrenoceptors are members of the G-protein-coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.The Adrenoceptors are divided into three types: a1, a2 and b-Adrenoceptors. Each type is further divided into at least three subtypes: a1A, a1B, a1D, a2A, a2B, a2C, b1, b2, b3. 1,2 The Adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system.1,2
b2-Adrenoceptors are mainly postsynaptic receptors. They are expressed on a number of tissues including blood vessels, bronchi, gastrointestinal tract (GIT), skeletal muscle, liver and mast cell.3 Functional b2-Adrenoceptors were also found on lymphocytes, macrophages and neutrophils.4,5 They are also the only b-Adrenoceptor subtype expressed in keratinocytes, fibroblasts and melanocytes. 3 Activation of b2-Adrenoceptors results in vasodilation, relaxation of the GIT, inhibition of histamine release from mast cells and bronchodilation. Selective agonists of b2-Adrenoceptors are used to treat asthma and other related bronchospastic conditions such as Chronic obstructive pulmonary disease (COPD).5
Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of the mouse b2-Adrenoceptor. The Anti-b2-Adrenoceptor (extracellular) antibody (#AAR-016) can be used for Western blot analysis. It has been designed to recognize b2-Adrenoceptor from mouse, rat and human samples.