Anti-Alpha 1 Na+/K+ ATPase Antibody
Antibodies
Description
Na+/K+-ATPase a membrane protein located on the plasma membrane of all animal cells, is involved in maintaining the Na+ and K+ gradient across the cell membrane1. It is ubiquitously expressed in neurons and helps maintain normal neuronal function2. The enzyme is composed of a catalytic a chain of 112 kDa. and α glycosylated β chain of 40–50 kDa.3. There are four isoforms of the α subunit (α1, α2, α3 and α4) and three isoforms of the β subunit (β1, β2 and β3) with different tissue distributions4.
The N-terminus is on the cytoplasmic side of the membrane, four transmembrane segments in the first third of the polypeptide chain, a large cytoplasmic loop (LCL) comprising the second third of the chain and four to six transmembrane segments in the C-terminal third of the protein with the C-terminus on the cytoplasmic side of the membrane5.
Na+/K+-ATPase abnormalities have been reported to be involved in several neurological diseases such as seizures, bipolar disorder, spongiform encephalopathy, and Alzheimer’s disease. Na+/K+-ATPase may also have implications in behavioral defects6.
The N-terminus is on the cytoplasmic side of the membrane, four transmembrane segments in the first third of the polypeptide chain, a large cytoplasmic loop (LCL) comprising the second third of the chain and four to six transmembrane segments in the C-terminal third of the protein with the C-terminus on the cytoplasmic side of the membrane5.
Na+/K+-ATPase abnormalities have been reported to be involved in several neurological diseases such as seizures, bipolar disorder, spongiform encephalopathy, and Alzheimer’s disease. Na+/K+-ATPase may also have implications in behavioral defects6.