Anti-a2C-Adrenoceptor (extracellular)
- 貨號 Cat. No.
- AAR-022
- 規格 Size
- 50 µl 0.2 ml
Description
Anti-a2C-Adrenoceptor (extracellular)
| Product#: | AAR-022 |
| Sizes: |
| 50 µl |
| 0.2 ml |
| Host: |
| Rabbit. Type: |
| Epitope: |
Peptide (C)RRPDGAAYPQ*SGLNDE, corresponding to amino acid residues 192-207 of rat a2C-Adrenoceptor with replacement of cysteine 202 (C202) with serine (*S) (Accession P22086).
|
 |
| Putative epitope location: |
2nd extracellular loop. |
| Homology: |
Rat, mouse - 15/16 amino acid residues identical; human - 14/16 amino acid residues identical. |
| Reactivity Confirmed: |
| Rat. |
Applications:
| Western Blotting: |
 | Western blot analysis of rat lung (lanes 1 and 4), kidney (lanes 2 and 5) and brain (lanes 3 and 6) membranes: 1, 2, 3. Anti-a2C-Adrenoceptor (extracellular) antibody (#AAR-022), (1:200). |
Adrenoceptors (also called Adrenergic receptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions.
The Adrenoceptors are members of the G-Protein Coupled Receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular N-terminus, and a cytoplasmic C- terminus.The Adrenoceptors are divided into three types: a1, a2 and b-Adrenoceptors. Each type is further divided into at least three subtypes: a1A, a1B, a1D, a2A, a2B, a2C, b1, b2, b31,2. The Adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system1,2.
The a2C-Adrenoceptor subtype was identified by binding studies in the opossum kidney and in cell lines from this organ (OK cells)3,4.
Surprisingly, the a2C-Adrenoceptor subtype seems not to play a major role in cardiovascular regulation or the other classical effects of a2-Adrenergic receptors5. Some researchers have suggested that the a2C-Adrenoceptor subtype may play a role in modulating motor behaviour and perhaps in memory processes6,7.
Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of rat a2C-Adrenoceptor. Anti-a2C-Adrenoceptor(extracellular) antibody (#AAR-022) can be used for Western blot analysis. It has been designed to recognize a2C-Adrenoceptor from rat, mouse and human samples.