Anti-5-Hydroxytryptamine Receptor 1A

Western blot analysis of 5-Hydroxytryptamine Receptor 1A in mouse brain membrane (lanes 1 and 3) and rat brain membrane proteins (lanes 2 and 4): 1,2. Anti-5-Hydroxytryptamine Receptor 1A antibody (#ASR-021), (1:200). 3, 4. Anti-5-Hydroxytryptamine Receptor 1A antibody, preincubated with the control peptide antigen.

Serotonin [5-hydroxytryptamine (5-HT1)] is an important neurotransmitter in the CNS that exerts its neuronal activity via 5-HT receptors.

5-HT receptors are subdivided into seven families termed 5-HT1 through 5-HT7.¹  The 5-HT receptor families belong to the G-Protein Coupled receptor superfamily with the exception of 5-HT3 receptor class which belongs to the ligand-gated ion channels. ²

The 5-HT1 receptor class comprises of five different receptors (5-HT1A, 5-HT1B, 5-HT1D, 5-HT1e AND 5-HT1F) which share 41-63% overall sequence identity and couple preferentially to G_i/G_o to inhibit cAMP formation.²

The 5-HT1A receptor is the most widespread of all the 5-HT receptors. In the central nervous system, 5-HT1A receptors exist in the cerebral cortex, hippocampus, septum, amygdala, and raphe nucelus in high densities, and was also demonstrated in a variety of tissues from various species.^2,3

Activation of 5-HT1A receptor decreases blood pressure and heart rate, involved in learning, memory, relieving anxiety and depression. ^1,4

Alomone Labs is pleased to offer a highly specific antibody directed against an intracellular epitope of the rat 5-Hydroxytryptamine Receptor 1A (5-HT1A).  Anti-5-Hydroxytryptamine Receptor 1A  antibody (#ASR-021) can be used for Western Blotting application. It has been designed to recognize rat 5-Hydroxytryptamine Receptor 1A from rat and mouse samples.