Anthopleurin-C (APE2-1)
- 貨號 Cat. No.
- A-400
- 規格 Size
- 5 μg 5x5 μg 10μg 5x10μg 0.1mg
Description
Anthopleurin-C (APE2-1)
A Potent Activator of Nav Channels
| Product#: | A-400 |
| Sizes: |
| 5 mg |
| 5 x 5 mg |
| 10 mg |
| 5 x 10 mg |
| 0.1 mg |
| M.W.: | 4884 |
| Purity: | >95% |
| Bioassay: |
| Enhancement of Nav currents in differentiated PC-12 cells by low APE2-1 concentrations. |
 |
| Activation of Nav channels current in NGF treated PC-12 cells by 5 nM APE2-1. Current traces recorded in a typical cell before (red) and during (black) application of APE2-1. Holding potential was -120 mV and a test pulse to -20 mV was delivered every 10 seconds. |
| References: |
1. | Norton, T.R. (1981) Federation Proc. 40, 21. |
2. | Bruhn, T. et al. (2001) Toxicon 39, 693. |
A potent cardiotoxin, which evokes a positive inotropic and chronotropic effect on mammalian heart muscle.1,2 Recently it was found that this toxin modifies the current passing through the fast Na+ channel in neuroblastoma cells, leading to delay and incomplete inactivation.2
Effective at concentrations of 1-5nM in isolated guinea-pig atria.2