Antazoline hydrochloride

Antazoline hydrochloride is a first generation antihistamine, binding to the histamine H1 receptor and blocking the action of endogenous histamine.On insulin secretion, the two imidazolines (antazoline and efaroxan), induced a concentration-dependent response.Antazoline being 10 times more potent than efaroxan. In contrast, idazoxan, a blocker of imidazoline I1 sites,when the concentrations up to 30 microM, it antagonized the insulin response to 10 microM efaroxan (IC50 approximately equal to 14 +/- 2 microM) without affecting that to 3 microM tolbutamide.