Annexin II Antibody

Annexins are a multigene family of Ca++-regulated phospholipid-binding proteins. They serve as membrane-membrane, or membrane-cytoskeleton linkers, and regulate the formation of lipid domains in the plasma membrane. Annexins possess a series of unique 70 amino acid annexin-repeat modules that form a curved disk and allow for the creation of an intercessory complex between plasma membrane and cytofilaments. Annexin II is a heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Annexin II interacts with ATP1B1 and DYSF. Annexin II also interacts with human cytomegalovirus (HCMV).