Annexin A11 Antibody

Annexins are a multigene family of Ca++-regulated phospholipid-binding proteins. They serve as membrane-membrane, or membrane-cytoskeleton linkers, and regulate the formation of lipid domains in the plasma membrane. Annexins possess a series of unique 70 amino acid annexin-repeat modules that form a curved disk and allow for the creation of an intercessory complex between plasma membrane and cytofilaments. Annexin A11 binds specifically to calcyclin in a calcium-dependent manner. Annexin A11 is required for midbody formation and completion of the terminal phase of cytokinesis.