Anamorelin

Anamorelin significantly increased both lean body mass and body weight, and also improved appetite, in patients with advanced lung cancer and cachexia and anorexia in 2 clinical trials. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite.