ANA Screen

Autoimmune diseases are characterized by an abnormal
functioning of the immune system which mistakenly attacks
healthy body tissue. It results in a change of the
mechanisms of cell recognition, the organism no longer
distinguish the self from not-self, ie the elements
belonging to it and those that do not. This leads to
production of antibodies that can affect individual organs or
trigger systemic diseases, damaging entire functions of the
individual.
The processes that lead to serious autoimmune diseases
are still unknown in many ways.
Rheumatic autoimmune diseases are often associated with
the presence of many autoantibodies directed against
nuclear and cytoplasmic antigens. These antibodies are
commonly called antinuclear antibodies (ANA) and their
presence is important to reveal different rheumatic
diseases such as systemic lupus erythematosus (SLE),
Sjögren syndrome, scleroderma and mixed connective
tissue disease (MCTD).
The presence of antinuclear antibodies (ANA) can be
detected with IFA technique or with an ELISA test.
The advantages of ELISA tests are: ease of use, no
interpretater influence and lower false positives sample.