Amylin Peptide

polypeptide (IAPP), is a 37-amino acid monomeric polypeptide isolated from pancreatic amyloid, which is commonly found in the islet of patients with diabetes mellitus type II and in insulinomas. Amylin is derived from a larger propeptide precursor of 89 amino acids in humans. Immunostaining of amylin is found in islet amyloid and in cells of the islets of Langherans, where it colocolizes with insulin in islet B cells. This peptide corresponds to full-length amylin (residues 34-70 of human amylin precursor) with a Cys2-Cys7 disulfide bridge and an amidated C-terminus end.