Aminoglutethimide

Aminoglutethimide (Cytadren) is an inhibitor of adrenocortical steroid synthesis. It blocks aromatase in the generation of estrogens from androstenedione and testosterone. It also blocks the conversion of cholesterol to pregnenolone by inhibiting the enzyme P450scc and consequently decreases synthesis of all hormonally active steroids. It inhibited bovine adrenal cholesterol side-chain cleavage activity with an IC50 value of 40 μM.