AMIGO-2 Antibody

Amphoterin-induced protein 2 (AMIGO-2) is required for depolarization-dependent survival of cultured cerebellar granule neurons. AMIGO-2 mediates homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. AMIGO-2 contributes to signal transduction through its intracellular domain, and is be required for tumorigenesis of a subset of gastric adenocarcinomas. AMIGO-2 is differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.