Alpha1-Antitrypsin (3B7) Antibody

Catalog Number

250380

Unit

0.1 mg

 

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.

Data and Images

Description

The serum glycoprotein a1-antitrypsin also called a1- AT, is a typical member of the serpin family (serine protease inhibitors), and, an inhibitor of trypsin. a1- AT is synthesized in the liver thus as a single polypeptide chain of approximately 51 kDa showing a marked degree of genetic polymorphism due to the presence of over 20 different alleles. Individuals homozygous for a1- AT deficiency are predisposed to pulmonary emphysema and hepatic cirrhosis. This antibody is specific for human a1- AT (native and denatured).

Product Citations

Recommended Products

Alternate Names

Alpha-1 protease inhibitor;  Alpha-1-antiproteinase

Accession No.

P01009

 

Clonality

3B7

Antigen

 a1-  AT isolated from human plasma

Application Notes

Product Cat. No. 250380 reacts strongly in ELISA with native and denatured alpha1-AT coated directly onto the microtiter well. The antibody detects only native alpha1-AT in sandwich ELISA with a polyclonal capture antibody. Product Cat. No. 250380 reacts in western blot with native and denatured alpha1-AT in reduced as well as non-reduced forms.

E: 1:15,000

WB: 1:1,000

Reacts with  :H

Storage

Store at 4°C. Product is guaranteed 6 months from the date of shipment.