Alpha-Actinin Antibody

Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle alpha-actinin isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.