Alpha-5 Integrin Antibody

Catalog Number

250731

Unit

0.1 mg

 

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Data and Images

Description

The integrin alpha-5 antibody recognizes the 115-kDa transmembrane glycoprotein integrin alpha-5 subunit which is the common alpha-5 chain of the very late antigen (VLA) forming a non-covalent heterodimeric complex with the integrin beta-1 subunit, a receptor for fibrinogen and extracellular matrix proteins such as fibronectin. Alpha-5/beta-1 integrin is an important adhesion molecule involved in cell-cell and cell-extracellular matrix interactions by recognizing the RGD canonical sequence in ligands. In addition to adhesion, integrins are known to participate in cell-surface mediated signaling.

Product Citations

Recommended Products

Alternate Names

Integrin alpha-5; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD49 antigen-like family member E; CD49e; ITGA5; FNRA

Accession No.

P08648

 

Clonality

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human integrin alpha-5.

Application Notes

E: 1:500-1:1,000

WB: 1:200-1:500

IHC: 1:200-1:500

Reacts with  :H | M | R | Other

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.