AKAP-10 Antibody

A-kinase anchor protein 10, mitochondrial (AKAP-10) is a differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one hypothesis that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. PKA, via its RGS domain, provides a link between the signaling machinery and downstream kinaes.