Agrin Antibody

Agrin is an essential extracellular matrix component that causes clustering of nicotinic acetylcholine receptors (nAChRs) and acetylcholine-esterase on the surface of muscle fibers of the neuromuscular junction. Agrin, MuSK and rapsyn are all essential components for AChR aggregation. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites increasing the predicted MW from 200 kDa to 600 kDa.