Agomelatine

Agomelatine is an extremely potent agonist at both melatonin receptors (MT1 and MT2), with additional antagonism at 5HT2C. Agomelatine is a novel antidepressant with many desired in vivo properties, including neuroprotection and neurogenesis in depression-sensitive brain areas. Agomelatine abolishes 5-HT2C agonist effects both in cells and in vivo. Agomelatine also dose dependently increases extracellular levels of noradrenaline and dopamine in frontal cortex of freely moving rats.