ADMA (Mouse/Rat) ELISA

pADMA (Mouse/Rat) ELISA/p
pimg alt=For Research Use Only src=http://www.alpco.com/img/ruo.gif align=absMiddle / For Research Use Only/p
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div class=prod_specbFormat:/b/div
div class=prod_spec_infoELISA / EIA/div
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div class=prod_specSample Type:/div
div class=prod_spec_infoserum, EDTA plasma/div
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div class=prod_specbSample Size:/b/div
div class=prod_spec_info100 micro;l/div
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div class=prod_specbSize:/b/div
div class=prod_spec_info96 wells/div
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div class=prod_specbRange:/b/div
div class=prod_spec_info0.1 - 3 micro;mol/l/div
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div class=prod_specbSensitivity:/b/div
div class=prod_spec_info0.05 micro;mol/l/div
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div class=prod_specbIncubation Time:/b/div
div class=prod_spec_infoOvernight/div
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pbSummary:/b/p
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NO-synthase. It isbr /
formed during proteolysis of methylated proteins and removed by renal excretion orbr /
metabolic degradation by the enzyme dimethylarginine dimethylaminohydrolasebr /
(DDAH). Several cell types, including human endothelial and tubular cells, are capablebr /
of synthesizing and metabolizing ADMA. Elevated ADMA concentrations in the bloodbr /
are found in numerous diseases associated with endothelial dysfunction. For example, elevated ADMA levels in the blood of individuals on dialysis correlate significantly with the degree of arteriosclerosis and cardiovascular risk. Furthermore, elevated ADMA levels are found in individuals with hypercholesterolemia, hypertension, arteriosclerosis, chronic renal failure, and chronic heart failure, and are associated with restrictions in endothelial vasodilatation./div
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