ADD1 (K720) Antibody

貨號 Cat. No.

BS1005

規格 Size

100μg

品牌 Brand

Bioworld

Description

 

stock

Host: Rabbit

Reactivity: Human,Mouse,Rat

Product

1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Purification & Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity

ADD1 (K720) antibody detects endogenous levels of ADD1 protein.

Applications (Recommended Dilutions)

WB: 1:500~1:1000 IHC: 1:50~1:200 IP: 1:50~1:200 IF: 1:50~1:200

Western Blot(WB)

Western blot (WB) analysis of ADD1 (K720) antibody in extracts from HeLa cells.

Immunohistochemistry (IHC)

Immunohistochemistry (IHC) analyzes of ADD1 (K720) antibody in paraffin-embedded human brain tissue.

Storage&Stability

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Background

Adducins are a family of cytoskeletal proteins encoded by three genes (alph,a bet,a gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha and beta adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha and gamma adducins are ubiquitously expressed. In contrast, beta adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca2+/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.

 

 

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