ActiveMax® Mouse VEGF120 Protein, Tag Free

Source : 

ActiveMax® Mouse VEGF120, Tag Free (VE0-M4211) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Arg 146 (Accession # AAB22254.1 ).

 

Molecule : VEGF120

 

Synonyms : RP1-261G23.1,MGC70609,MVCD1,VEGFA,VPF

 

Format : Powder

 

Category : ActiveMax® Cytokines

 

Accession : AAB22254.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 14.1 kDa

 

Characteristics :

This protein carries no "tag". The protein has a calculated MW of 14.1 kDa. The protein migrates as 18-22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Vascular endothelial growth factor A (VEGFA) is also known as Vascular permeability factor (VPF). VEGFA belongs to the PDGF/VEGF growth factor family. VEGFA is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. VEGFA is produced by a group of three major isoforms as a result of alternative splicing and if any three isoforms are produced (VEGFA120, VEGFA164, and VEGFA188) then this will not result in vessel defects and death of the full VEGFA knockout in mice.

 

References :

(1) Shin S.-Y., et al., 2005, Yonsei Med. J. 46:679-686.
(2) Breier G., et al., 1992, Development 114:521-532.