ActiveMax® Human IL-4 Protein, Tag Free

Source : 

ActiveMax® Human IL-4, Tag Free (IL4-H4218) is expressed from human 293 cells (HEK293). It contains AA His 25 - Ser 153 (Accession # P05112-1).

 

Molecule : IL-4

 

Synonyms : IL4,BCGF1,BSF1

 

Format : Powder

 

Category : ActiveMax® Cytokines

 

Accession : AAH67514

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 15.0 kDa

 

Characteristics :

This protein carries no "tag". The protein has a calculated MW of 15.0 kDa. The protein migrates as 15 kDa and 19 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 0.1 EU per μg by the LAL method.

 

Buffer : PBS and NaCl

 

Description :

Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

 

References :

(1) Callard RE., et al., 1991, Br J Haematol. Jul;78(3):293-9.
(2) Varin A, Gordon S., et al., 2009, Immunobiology. 214(7):630-41.
(3) Finkelman FD, et al., 2004, Immunol Rev. 201:139-55.
(4) Lee YJ, Jameson SC,et al., 2011, Trends Immunol. 32(2):50-6. Epub 2011 Feb 1.