ActiveMax® Human IFN-gamma / IFNG Protein, Tag Free

Source : 

ActiveMax® Human IFN-gamma, Tag Free (IFG-H4211) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Gln 166 (Accession # AAH70256).

 

Molecule : IFN-gamma

 

Synonyms : Interferon-gamma ,Interferon-γ

 

Format : Powder

 

Category : ActiveMax® Cytokines

 

Accession : AAH70256

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 16.8 kDa

 

Characteristics :

This protein carries no "tag". The protein has a calculated MW of 16.8 kDa. The protein migrates as 19-25 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Interferon-gamma (IFN-γ/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. IFN-gamma has been used in a wide variety of clinical indications. Interferon-gamma (IFNgamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.

 

References :

(1) Gray PW, et al., 1982, Nature 298 (5877): 859–63.
(2) Miller CH, et al., 2009, Ann N Y Acad Sci.1182:69-79.
(3) Saha B, et al., 2010, Cytokine. 50(1):1-14.
(4) Murphy SP, et al., 2009, Biol Reprod. 80(5):848-59.