ActiveMax® Human CCL19 / MIP-3 beta Protein, Tag Free

Source : 

ActiveMax® Human CCL19 / MIP-3 beta, Tag Free (CC9-H5215) is expressed from human 293 cells (HEK293). It contains AA Gly 22 - Ser 98 (Accession # Q99731-1).

 

Molecule : CCL19

 

Synonyms : CCL19,MIP-3 beta,MIP-3-beta,ELC,MIP3B,SCYA19,EBI1 ligand chemokine

 

Format : Powder

 

Category : ActiveMax® Cytokines

 

Accession : N/A

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 8.8 kDa

 

Characteristics :

This protein carries no "tag". The protein has a calculated MW of 8.8 kDa. The protein migrates as 12 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

C-C motif chemokine 19(CCL19) is as known as CK beta-11, ELC, MIP3B and SCYA19. May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

 

References :

(1) Kim CH, et al. J Immunol. 1998. 160(5):2418-24.
(2) Adachi K, et al. Nat Biotechnol. 2018. 36(4):346-351.