Acinus Polyclonal Antibody
- 貨號 Cat. No.
- 3200-100
- 規格 Size
- 100 ug
Description
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pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide corresponding to residue surrounding amino acid 1332 of human AcinusL./p
pbFORMULATION: /b100 ug (0.5 mg/ml) immunoaffinity purified, rabbit anti-Acinus polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal./p
pbSPECIES REACTIVITY: /bhuman, mouse/p
pbSTORAGE CONDITIONS: /bStore at -20oC. For optimal storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND: /bAcinus (for apoptotic chromatin condensation inducer in the nucleus) is a ubiquitously expressed inducer of chromatin condensation, a hallmark of apoptosis. Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS?./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blotting (0.5-4 ug/ml) and immunofluorescence (4-8 ug/ml). However, the optimal conditions should be determined individually./p
pbSPECIFICITY: /bThe immunoaffinity purified antibody detects an approximate 220 kDa human Acinus. K562 cell lysate can be used as positive control./p
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pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide corresponding to residue surrounding amino acid 1332 of human AcinusL./p
pbFORMULATION: /b100 ug (0.5 mg/ml) immunoaffinity purified, rabbit anti-Acinus polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal./p
pbSPECIES REACTIVITY: /bhuman, mouse/p
pbSTORAGE CONDITIONS: /bStore at -20oC. For optimal storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND: /bAcinus (for apoptotic chromatin condensation inducer in the nucleus) is a ubiquitously expressed inducer of chromatin condensation, a hallmark of apoptosis. Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS?./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blotting (0.5-4 ug/ml) and immunofluorescence (4-8 ug/ml). However, the optimal conditions should be determined individually./p
pbSPECIFICITY: /bThe immunoaffinity purified antibody detects an approximate 220 kDa human Acinus. K562 cell lysate can be used as positive control./p