Acetylcholinesterase (12B4) Antibody

Catalog Number

250342

Unit

0.2 mg

 

Format

Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.

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Description

Acetylcholinesterase (AChE, EC.3.1.1.7.) is an enzyme located in the postsynaptic membrane and in the muscle endplates, where it hydrolyses the neurotransmitter acetylcholin. AChE from brain is a tetramer (G4-AChE) with a molecular mass of  320 kDa, AChE from erythrocytes is a dimer (G2-AChE) with a molecular mass of 170 kDa. This antibody is specific for human acetylcholinesterase. No cross-reaction is seen with human BtChE and AChE from flounder or Torpedo marmorata.

Product Citations

Recommended Products

Alternate Names

AChE

Accession No.

P22303

 

Clonality

12B4

Antigen

Brain acetylcholinesterase, human, purified and detergent solubilized (1).

Application Notes

Product Cat. No. 250342 reacts with both G2-and G4-AChE (native detergent soluble) in  ELISA and EAIA using the antibody as capture antibody. Product Cat. No. 250342 reacts 17-fold stronger with human brain AChE than with human erythrocyte AChE.

E: 1:4,000

WB: 1:500

Reacts with  :H

Storage

Store at 4°C. Product is guaranteed 6 months from the date of shipment.