ABIN-2 Polyclonal Ab
- 貨號 Cat. No.
- 3402-100
- 規格 Size
- 100 ug
Description
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pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide of human ABIN-2/p
pbFORMULATION: /b100 ug (0.5 mg/ml) purified rabbit anti-ABIN-2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal./p
pbSPECIES REACTIVITY: /bhuman, mouse/p
pbSTORAGE CONDITIONS: /bStore at -20oC. For long-term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND: /bABIN-2 binds to the COOH-terminal zinc finger domain of A20. NF-kB activation induced by TNF and interleukin-1 is inhibited by overexpression of ABIN-2. The latter also inhibits NF-kB activation induced by overexpression of receptor-interacting protein or TNF receptor-associated factor 2. A-20 binding Inhibitor of Nuclear Factor-kappaB (NF-kB) activation (ABIN-2) binds to A-20. ABIN-2 interferes with NF-kB activation upstream of the IKK complex and might contribute to NF-kB inhibitory function of A-20./p
pbSPECIFICITY: /bThe antibody detects 66 kDa ABIN-2 from samples of human and mouse origin./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blotting (1-4 ug/ml). However, the optimal conditions should be determined individually. Mouse lung tissue lysate can be used as a positive control./p
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pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide of human ABIN-2/p
pbFORMULATION: /b100 ug (0.5 mg/ml) purified rabbit anti-ABIN-2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal./p
pbSPECIES REACTIVITY: /bhuman, mouse/p
pbSTORAGE CONDITIONS: /bStore at -20oC. For long-term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND: /bABIN-2 binds to the COOH-terminal zinc finger domain of A20. NF-kB activation induced by TNF and interleukin-1 is inhibited by overexpression of ABIN-2. The latter also inhibits NF-kB activation induced by overexpression of receptor-interacting protein or TNF receptor-associated factor 2. A-20 binding Inhibitor of Nuclear Factor-kappaB (NF-kB) activation (ABIN-2) binds to A-20. ABIN-2 interferes with NF-kB activation upstream of the IKK complex and might contribute to NF-kB inhibitory function of A-20./p
pbSPECIFICITY: /bThe antibody detects 66 kDa ABIN-2 from samples of human and mouse origin./p
pbAPPLICATION AND USAGE: /bThe antibody can be used for Western blotting (1-4 ug/ml). However, the optimal conditions should be determined individually. Mouse lung tissue lysate can be used as a positive control./p
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