Abi-1 Antibody
Antibodies
- 貨號 Cat. No.
- 251822
- 規格 Size
- 0.1 mg
- 品牌 Brand
- Abbiotec
- Application 應用
- ELISA 、 IHC 、 WB
- Reactivity
- Human 、 Mouse
Description
Abelson interactor 1 (Abi-1) negatively regulates cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Abi-1 plays a role in regulation of EGF-induced Erk pathway activation. Abi-1 is involved in cytoskeletal reorganization and EGFR signaling, and together with EPS8 participates in transduction of signals from Ras to Rac. A chromosomal aberration involving Abi-1 is a cause of acute leukemias.
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