A-966492
Chemical Compounds
- 貨號 Cat. No.
- M3410
- 規格 Size
- 5mg,10mg,50mg
- 品牌 Brand
- No Brand
Description
A-966492 is a highly potent and efficacious poly (ADP-ribose) polymerase (PARP) inhibitor with a Ki and EC50 of 1 nM. In addition, it is orally bioavailable across multiple species, crosses the blood-brain barrier, and appears to distribute into tumor tissue. It also demonstrated good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with temozolomide and in an MX-1 breast cancer xenograft model both as a single agent and in combination with carboplatin.
