6'-Iodoresiniferatoxin

貨號 Cat. No.: I-805
規格 Size: 0.5 mg 5x0.5 mg 1mg

Description

6'-Iodoresiniferatoxin

An Agonist of the TRPV1

Product#:

I-805

Sizes:

0.5 mg

5 x 0.5 mg

1 mg

M.W.:

754.62

Purity:

>98%

Bioassay:

6?Iodoresiniferatoxin (6?IRTX) induced Ca²⁺ influx via activation of TRPV1 (Vanilloid Receptor 1 (VR1), TRPV1).

VR1 stably expressed HEK-293 cells were loaded with 2mM flou-3 AM and then stimulated with 6?Iodoresiniferatoxin (#I-805). The left panel shows the intracellular Ca²⁺ levels 10 sec post stimulation with different concentrations of 6?Iodoresiniferatoxin (ED₅₀=0.8mM) and plotted against drug concentration. The right panel shows intracellular Ca²⁺ levels before and after stimulation of cells with 2.5 mM 6? Iodoresiniferatoxin

References:

1.	McDonnell, M.E. et al. (2002) Bioorg. Med. Chem. Lett.12, 1189.

6?Iodoresiniferatoxin is an agonist of the TRPV1 (Vanilloid/capsaicin receptor) channel.¹ It is an iodinated form of the potent agonist Resiniferatoxin (#R-400). It displayed high affinity binding (K_i=0.71 nM) for the human TRPV1 receptor and functioned as a partial agonist.¹

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