5'-Iodoresiniferatoxin

貨號 Cat. No.: I-800
規格 Size: 0.5 mg 5x0.5 mg 1mg

Description

5'-Iodoresiniferatoxin

A Potent and Partial Antagonist of the TRPV1

Product#:

I-800

Sizes:

0.5 mg

5 x 0.5 mg

1 mg

M.W.:

755.62

Purity:

>99%

Bioassay:

5?Iodoresiniferatoxin (5?IRTX) inhibits Capsiacin induced Ca²⁺ influx via activation of TRPV1 (Vanilloid Receptor 1 (VR1), TRPV1).

VR1 was stably expressed in HEK-293 cells. The cells were loaded with 1 mM flou-3 AM and then stimulated with 10 mM Capsiacin in the absence (blue) or presence (purple) of 100 nM and 200 nM (green) 5?IRTX (#I-800) The figure shows intracellular Ca²⁺ levels before and after stimulation of cells with 10 mM Capsiacin.

References:

1.	Wahl, P. et al. (2001) Mol. Pharmacol. 59, 9.
2.	Wu, Z.Z. et al. (2005) J. Biol. Chem. 280, 18142.

5?Iodoresiniferatoxin (5?IRTX) is a potent and partial antagonist of the TRPV1 (Vanilloid/capsaicin receptor) channel.¹ It is an iodinated form of the potent agonist Resiniferatoxin (#R-400). 5?Iodoresiniferatoxin partially blocked capsaicin induced currents in Xenopus oocytes expressing TRPV1 channels (IC₅₀=3.9 nM).¹ 5?Iodoresiniferatoxin abolished an inhibitory effect of capsaicin on Ca_v currents (probably mediated by TRPV1) in DRG neurons.²

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