11-Desoxycortisol RIA

p11-Desoxycortisol RIAbr /
img alt=For Research Use Only src=http://www.alpco.com/img/ruo.gif align=absMiddle / For Research Use Only/p
div class=prod_head_infohr /
/div
div class=prod_spec_box
div class=prod_specFormat:/div
div class=prod_spec_infoRadioimmunoassay/div
/div
div class=prod_spec_box
div class=prod_specSample Type:/div
div class=prod_spec_infoserum/div
/div
div class=prod_spec_box
div class=prod_specbSample Size:/b/div
div class=prod_spec_info25 micro;l/div
/div
div class=prod_spec_box
div class=prod_specbSize:/b/div
div class=prod_spec_info96 wells/div
/div
div class=prod_spec_box
div class=prod_specbRange:/b/div
div class=prod_spec_info0.3 - 65 ng/ml/div
/div
div class=prod_spec_box
div class=prod_specbSensitivity:/b/div
div class=prod_spec_info0.04 ng/ml/div
/div
div class=prod_spec_box
div class=prod_specbIncubation Time:/b/div
div class=prod_spec_info2 Hour 30 Min/div
div class=prod_spec_info
pbSummary:/b/p
The 11-Desoxycortisol (Compound S) is an intermediate steroid in the biosynthesis of glucocorticoids. As a precusor of cortisol, it comes from 17-hydroxyprogesterone after action of the 11-beta-hydroxylase. This parameter is interesting for the study of surrenal enzymatic deficiency in 11-beta-hydroxylase, which is responsible for congenital surrenal hyperplasia in children and hyperandrogenics in adult women. Under hypothalamic-pituitary control via the Adrenocorticotropic hormone (ACTH), the secretion of 11-Desoxycortisol follows a nycthemeral variation: it reaches a maximum in the morning (around 8 a.m.) and a minimum during the night (between 0 to 4 a.m.) br /
br /
The measure of 11-Desoxycortisol can be performed in serum using immunological competition methods (RIA)./div
/div