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| Molecular interaction analyses have become invaluable tools in modern biomedical
and life science research. They enable scientists to unravel the complex
biological processes, identify potential drug candidates, understand drug-target
binding kinetics, and accelerate with the discovery of novel therapeutics. |
| At MedChemExpress (MCE), we offer a comprehensive suite of cutting-edge
molecular interaction detection technologies to support your research
requirements.
Here’s a glimpse of our advanced services: |
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MedChemExpress (MCE) Services: |
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| Methods |
Features |
Applications |
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Surface Plasmon Resonance (SPR)
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Data*: KD, Ka, Kd |
• Proteins
• Small molecules
• Peptides
• Nucleic acids
• Liposomes
• Lipids
• Polysaccharides
• Cells
• Cell lysates
• and more |
| Advantages: High sensitivity,
real-time kinetics, label-free, versatility |
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Microscale Thermophoresis (MST)
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Data: KD |
| Advantages: Preferred for weak affinity, detection is
not limited by buffer |
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Isothermal Titration Calorimetry (ITC)
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Data: KD, stoichiometric ratio (n), entropy change (△H),
enthalpy change (△S) |
| Advantages: Simulate reactions under physiological
conditions and measure thermodynamic data |
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Bio-Layer Interferometry (BLI)
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Data: KD, Ka, Kd |
| Advantages: Simple operation,
high-throughput detection possible |
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nano-Differential Scanning Fluorimetry (nanoDSF)
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Data: Melting temperature (Tm) |
| Advantages: Detection under natural conditions, study of
protein stability |
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| * KD: affinity constant, Ka: association rate constant, Kd: dissociation rate
constant |
| SPR-the “gold standard” for molecular interaction detection |
| Surface Plasmon Resonance (SPR) is a highly sensitive, label-free biosensing
technology that provides real-time binding kinetics and affinity data by
monitoring the interactions of biomolecules on metal film surfaces. |
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| Figure 1. Schematic diagram of SPR principle (concept image from MCE). |
| At MCE, we are committed to offering a comprehensive suite of drug screening
services with our one-stop platform. We have experienced experts and
cutting-edge facilities for Surface Plasmon Resonance (SPR), Microscale
Thermophoresis (MST), Isothermal Titration Calorimetry (ITC), Bio-Layer
Interferometry (BLI) and nano-Differential Scanning Fluorimetry (nanoDSF).
Whether you’re exploring protein stability, evaluating drug-target interactions,
or screening potential drug candidates, MCE’s advanced technologies and
expertise are here to support your research goals. |
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| Figure 2. Schematic diagram of molecular interaction analysis technologies
(concept image from MCE). SPR; MST; BLI; ITC; nanoDSF. |
MCE Advantages |
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Products are for research use only and are not intended for human use. We do
not sell to patients.
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