ACROBiosystems | 用於 ADC Linker 篩選和驗證的蛋白酶 (Proteases)

科技新知

 

78fe8e7b-25c2-44f1-ba88-0bd67401a22e image

In the development of antibody-drug conjugates (ADCs), the linker plays a crucial role by connecting the antibody and cytotoxic payload, influencing key properties such as stability, potency, safety, and pharmacokinetics (PK). Selecting the appropriate linker is paramount for maximizing the therapeutic efficacy and safety of ADCs.

 

Explore our ADC proteases for peptide linkers to power your screening and validation of ADC linkers!

Our feature product encompassing:

·    Cathepsin B, Cathepsin L, Cathepsin S

·    MMP-2, MMP-7, MMP-9 

·    β-glucuronidase, β-galactosidase

 

 
Product Features

 

·    Natural conformation: HEK293 expressed protein to ensure the natural structure

·    Robust and consistent enzyme activity, ensuring reproducibility across batches

·    High purity: Verified by SDS-PAGE and SEC-MALS

Case Show

Case studies show that ADC DS-8201 can be cleaved by Cathepsin B from ACROBiosystems

 
 

1e322332-cd96-4f60-a197-e707439e9a8b image

 

Awards & Certifications

 

 

 

 

 

 

 

ACROBiosystems | 1 Innovation Way | Newark, DE 19711 US

 

▲ LINE
諮詢