ACROBiosystems | 全民減重總動員:減重核心靶點與相關產品療法介紹

科技新知

 

肥胖已成為全球性的重大健康挑戰,其形成與生活方式及膳食結構的轉變密切相關。肥胖問題不僅影響體態外觀,更是糖尿病、心血管疾病、癌症、神經退行性疾病及心理健康問題的重要風險因素,給公共衛生系統帶來沉重負擔。面對這一涉及多方面的健康危機,深入探究肥胖的病因學及調控機制,或為開發針對相關併發症的有效治療幹預措施奠定科學基礎。

 

https://www.bmisurgery.com/health-risks-tied-to-obesity-2

與肥胖相關的健康風險 – BMI指數

 
 
 

ACROBiosystems百普賽斯針對減重病理機制中的核心靶點,構建了覆蓋GLP-1R、GCGR、GIPR、GPR75、GDF-15、FGF-21、Activin R的重組蛋白、功能細胞株等產品,全面助力減重相關靶向藥物及療法開發。

 
 

驗證資料

 

GLP-1R蛋白:親和力經SPR驗證

 

GLP1R agonist captured on Protein A Chip can bind Human GLP1R Full Length Protein, Flag, His Tag (Cat. No. GLR-H52D4) with an affinity constant of 2.74 µM as determined in a SPR assay (in presence of DDM and CHS) (Biacore 8K) (Routinely tested).

 

Activin RIIB蛋白:親和力經SPR驗證

 

Biotinylated Human Activin RIIB Protein, His,Avitag (Cat. No. ACB-H82E3) immobilized on CM5 Chip can bind Human Latent Activin A, His Tag (Cat. No. ACA-H424x) with an affinity constant of 0.147 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

 

GIPR穩定細胞株:高生物活性經FACS驗證

 

Flow cytometry surface staining of human GIPR on HEK293/Human GIPR Stable Cell Line (Cat. No. CHEK-ATP206, High Expression) demonstrates consistent mean fluorescent intensity across passage 8-23.

GDF-15蛋白:高生物活性經ELISA驗證

 
 
 

Immobilized Human GFR alpha-like, His Tag (Cat. No. GFA-H52H3) at 5 μg/mL (100 μL/well) can bind Human GDF-15, Fc Tag (Cat. No. GD5-H5269) with a linear range of 0.1-6 ng/mL (QC tested).

 
 

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