| The antibody pairs are the critical reagents for antigen test kits. However, for the antigen test development, the current dilemma is how to choose a sample for the assay development. Most of the scientists use recombinant antigen proteins as spiked in samples for the assay development due to the limitation caused by biosafety reasons for getting access to patient samples in the early discovery stage. The deficiency of this method is that the recombinant proteins may not best represent the structure of the virus. Additionally, the lysis of the swab samples will cause unwanted breakage of the proteins, which is the recombinant protein won’t be able to replicate. In summary, the recombinant protein is not sufficient enough when screening for the antibody pairs. |
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